5/5Eve Online is sometimes criticized for having endless drop-down menus and generally being a bit of a click fest. However, from my perspective this is absolutely fine. Combined with the fact that even Player vs Player combat is strategic, rather than twitchy, this makes Eve one of the easiest games to play. At least in a physical sense :)
It has one quirk, though. The double click speed is fixed and not set to the speed set in the operating system. This matters because that's too fast for me to double click with my feet, and it's how you manoeuvre in game. This is easily fixed by binding double click to the third button.
Mouse Bindingsleft button - Same as default profile
right button - Same as default profile
middle button - double click